|
KMID : 1134820180470090863
|
|
Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 9 p.863 ~ p.869
|
|
|
Inhibitory Effects of 20(S)-Ginsenoside Rg3 on Thromboxane A2 Generation via p38 Mitogen-Activated Protein Kinase
|
|
Kwon Hyuk-Woo
|
|
|
Abstract
|
|
|
|
Thromboxane A2 plays a central role in hemostasis and thrombus formation, which stimulates other platelets as an agonist leading intracellular signaling cascades. In this study, we tried to explain the inhibitory mechanism of 20(S)-ginsenoside Rg3 (G-Rg3) on thromboxane A2 production by assaying the activities of TXA2 production-associated microsomal enzymes and associated signaling molecules. Thrombin-stimulated human platelet aggregation was dose-dependently decreased by G-Rg3 and attenuated thromboxane A2 production via down regulation of microsomal cyclooxygenase-1 and thromboxane A2 synthase activities. In addition, arachidonic acid release, which is a precursor of TXA2 was decreased by G-Rg3 through dephosphorylation of cytosolic phospholipase A2 and p38 mitogen-activated protein kinase. Overall, the results revealed the specific signaling pathway of TXA2 production via G-Rg3. Therefore, G-Rg3 is a beneficial novel compound inhibiting TXA2 production, which may prevent platelet aggregation-mediated thrombotic disease.
|
|
|
KEYWORD
|
|
|
20(S)-ginsenoside Rg3, thromboxane A2, arachidonic acid, cyclooxygenase-1, thromboxane A2 synthase
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|